Technology & Innovation – Medtronic

WHO WE ARE

At Medtronic, we believe in the power of medical technology to improve lives. Seven decades ago, our co-founder invented the battery-powered pacemaker. Today, we are among the largest medical device companies in the world. With operations in 150 countries, our products treat 70 health conditions and include cardiac devices, cranial and spine robotics, insulin pumps, surgical tools, patient monitoring systems, and more. Our therapies help 72 million people a year and support our Mission to alleviate pain, restore health, and extend life.

Redefining life with Diabetes – For more than 35 years, Medtronic Diabetes has committed to drive innovation, including new insulin delivery solutions that make life easier by reducing the burden of diabetes and deliver strong clinical outcomes.

Let’s take healthcare Further, Together.

WHAT IS INSULIN PUMP THERAPY?

An insulin pump is a small device (about the size of a smartphone) that mimics some of the ways a healthy pancreas works. It is safe, discreet and reliable. It can be attached to the same sites you currently inject in and insulin is simply delivered to your body through a thin tube. An insulin pump replaces the need for frequent injections by delivering rapid acting insulin continuously 24 hours a day.

WHY USE INSULIN PUMP THERAPY?
90% Fewer injections^† LOWER – HBA1C^5,6

WHO CAN USE AN INSULIN PUMP?

Talk to your healthcare professional to see if you’re eligible for insulin pump therapy. Current guidance for adults and children is that an insulin pump may be considered for people who:

Have TYPE 1 diabetes
Take THREE OR MORE insulin injections per day
Can carbohydrate count or plan to receive CARBOHYDRATE COUNTING EDUCATION
Would like to BETTER MANAGE your diabetes. An insulin pump helps you to manage your diabetes. You will need to calculate your carbohydrate at mealtimes, and the pump delivers tiny amounts of insulin in the background throughout the day, to replace your basal insulin.

INSULIN PUMP THERAPY BENEFITS

Insulin pump therapy offers several benefits over multiple daily injection therapy. With our pump and sensor system, you’re more likely to:

Keep your glucose levels in range^1,2,3,4
Lower HbA1c^5,6
Higher time in range^1,2,5,8
Fewer hypoglycaemic events⁷
Live more, worry less
90% Less injections^†
74% Worry less about highs⁹
71% Worry less about low during sleep⁹
Focus on your life, not your glucose levels

MINIMED^TM 780G SYSTEM WITH GUARDIAN^TM 4 SENSOR

This is our most advanced insulin pump system, offering self-adjusting basal insulin and new autocorrection dosing* compared with the MiniMed^TM 670G system.*
Can help you to achieve the Time in Range goal of over 70% and HbA1c goal** of 7.0%^{1, 3, 4, 8}

MiniMed^TM 780G system helps people spend on average 76% of time in target range³ and is automated* for an easier*** way to stabilise glucose levels^{1, 2, 3} with 90% fewer injections vs MDI^#

Trusted & Recommended

99% of people who previously used Multiple Daily Injections with is CGM*/CGM therapy, agreed that the MiniMed^TM 780G insulin pump system was better⁵.

Helps you to reach time in range and HBA1C goals^1,3,4,5
Automated to help you to reach your targets with less effort^1,2,3,4
We offer remote follow-ups and automatic uploads of patient data**

* A blood glucose (BG) reading is needed when entering SmartGuard^TM feature. If glucose alerts and CGM readings do not match your symptoms, use a BG meter to make diabetes treatment decisions. Refer to System User Guide – SmartGuard^TM feature. Some user interaction required. ** Refer to MiniMed^TM Mobile app User Guide.

SMARTGUARD^TM TECHNOLOGY

The MiniMed^TM 780G system continuously anticipates insulin needs, adjusts insulin delivery and corrects high sensor glucose automatically*, while helping to protect you

from lows^1,2. Automatic* adjustments and corrections help you focus on your life – not your glucose levels.

“Using this system was the 1st time in my life I have been able to switch off my mind to all the thoughts about control & treatment. I did not know how much mental space this took until I didn’t have to”
MiniMed^TM 780G system user

NOW WITH GUARDIAN^TM 4 SENSOR WITH NO FINGER PRICKS*^†

Our most advanced insulin pump system just got even better: the MiniMed^TM 780G system, is now available with Guardian^TM 4 sensor which requires no finger pricks*^†.

Speak to your Healthcare professional to discuss if you’re eligible to get the MiniMed^TM 780G System with Guardian^TM 4 Sensor.

MINIMED^TM MOBILE APP

Your glucose levels can now be viewed on your smartphone, allowing you to easily track your values and get notified on your phone if you’re going high or low. Available to download at no cost for most iOS and Android smartphones.

CARELINK^TM CONNECT APP

You can choose to share your real-time diabetes data with your care partners.

*Refer to CareLink^TM Connect app. Instructions for Use. CareLink^TM Connect app requires internet connection

FREQUENTLY ASKED QUESTIONS

Who is this insulin pump recommended for?

The MiniMed^TM 780G system is approved for people with type 1 diabetes, age 7 and above.

Does the system communicate with my smartphone?

Yes. With the MiniMed^TM 780G system you can easily track your glucose levels and view notifications and alerts on your smartphone. Up to 5 care partners can be invited to download the CareLink^TM Connect app and view your real-time glucose values on their phones. Available to download at no cost for most iOS and Android smartphones. To see if your smartphone is compatible, see this reference chart.

What’s so unique about the MiniMed^TM 780G system?

The MiniMed^TM 780G system automatically adjust insulin delivery to your needs for an easier way to stabilise glucose levels. It features an advance level of automation for diabetes management, known as SmartGuard^TM technology. If your glucose levels are trending high, it gives you more insulin. If they are trending low, it gives you less or no insulin at all. Now it can even correct high glucose levels in cases where carb counts aren’t exact.

How is this system different than using a pump by itself?

The MiniMed^TM 780G system, automatically adjust delivery of basal insulin based on Continuous Glucose Monitoring (CGM) values. This means that the pump gets glucose readings from the Guardian^TM Sensor 4 and transmitter automatically, and then delivers of a variable rate of insulin, every 5 minutes, 24 hours a day based on your personal needs. This integrated system – meaning having a pump and a CGM that speak to one another – can help to reduce both high and low glucose levels.

Do I still need to check my blood glucose with finger prick or give myself injections?

When you use an insulin pump, you have a dramatic reduction in injections – by up to 90%.* The infusion set that attaches to your body contains a small, flexible plastic cannula that is inserted to be placed under the skin and changed every 2-3 days. A CGM glucose sensor is inserted every 7 days. Using the SmartGuard^TM feature does not completely replace finger pricks but you will need to check your BG less frequently. This is because sensor readings are taken from your interstitial fluid (fluid surrounding the cells in your tissue) and not your blood, . With Guardian^TM 4 sensor and transmitter a blood glucose reading is needed when you first enter SmartGuard^TM feature,. If glucose alerts and CGM readings do not match your symptoms, use a blood glucose meter to make diabetes treatment decisions. It is important to know that all blood glucose values entered & accepted are used for calibration. Refer to System User Guide – SmartGuard^TM feature. Some user interaction required.

*Assumes four injections per day for 30 days and one infusion set change every two to three days.

Is this pump waterproof?

*At the time of manufacture and when the reservoir and tubing are properly inserted, your pump is waterproof. It is protected against the effects of being underwater to a depth up to 3.6 metres for up to 24 hours. Although it’s designed to be waterproof, drops and bumps that occur over time can make it more vulnerable to damage from water. We recommend removing your pump before swimming or bathing. The sensor and transmitter are water-resistant at 2.4 metres for up to 30 minutes. CGM readings may not be transmitted from the sensor to the pump while in water.

EDUCATIONAL SUPPORT

Patient Webinars
Medtronic are offering a range of useful webinars with hints and tips for anyone with Type 1 Diabetes using the MiniMed^TM 780G pump or system. Each session will last 45 minutes – 1 hour.

To book please follow the link below, select which educational session you would like to attend and complete the registration.

Book here

Competitive sport

Impact of competitive, intense and/or extended duration exercise on blood glucose
How SmartGuard feature adapts to exercise
Case studies and experiences
Exercise protocol
Thursday 19.10.2023 – 13:00
Saturday 27.04.2024 – 10:00

Carb counting.

Bolusing with SmartGuard^TM feature
Methods to count carbs
Resources to help you with your carb counting
Protein and fat
Takeaways and eating out
The effect of alcohol on blood glucose
Monday 11.12.2023 – 18:00
Thursday 21.05.2024 – 13:00

Getting the basics right

Treating highs and lows
An introduction to CareLink^TM data
Tips to help you to get the most from your device
Tuesday 14.11.2023 – 13:00
Wednesday 21.02.2024 – 18:00

CareLink^TM and support for you

An overview of available reports
How to view your CareLink^TM reports
Understanding your data Goals
An introduction to HCL guidance and access
Additional Medtronic support available to you
Tuesday 27.06.2023 – 13:00
Monday 15.01. 2024 – 18:00

Exercise and activity

Benefits, recommendations and challenges
Impact of exercise on blood glucose
Strategies to help in manual mode
How SmartGuard^TM feature adapts to exercise Exercise protocol
Saturday 09.09.2023 – 10:00
Thursday 21.03.2024 – 13:00

Enjoying your holidays

Travelling abroad and longer journeys
The effect of temperature on you and your supplies
Medtronic services to support you travels
Preparing for unusual foods, drinks and activities
Wednesday 19.07.2023 – 18:00

Educational Support Videos

These 11 short instructional videos with safety instructions designed primarily for patients to use, are reminders and support for patients using Medtronic pumps and systems.

Watch Videos Here

Visit our website www.medtronic-diabetes.com for more information.

Medtronic Ltd, Building 9, Croxley Park, Watford. Tel:01923 205 167

REFERENCES
1. Carlson AL, et al. Poster # 97 at the 80th International Conference of the American Diabetes Association, June 2020, Chicago/Virtual.
2. Collyns OJ, et al. Diabetes Care. 2021;44(4):969-975.
3. Da Silva J, et al. Real-world Performance of the MiniMed^TM 780G System: First Report of
Outcomes from 4’120 Users. Diabetes Technol Ther. 2021; doi: 10.1089/dia.2021.0203.
4. Battelino T, et al. Diabetes Care 2019; 42(8): 1593-1603.
5. Medtronic data on file: MiniMed^TM 780G users survey conducted in April-May 2021 in UK,
Sweden, Italy, Netherlands and Belgium. Sample size = 789.
6. Medtronic data on file. MRM 17430 MiniMed^TM MioTM Advance claims from Human Factors
Testing.
7. Medtronic data on File IFU Comparison versus MiniMed^TM Quick Set.
8. ADA Guidelines of A1C<7.0 – www.Diabetes.org
9. Medtronic data on file: Pivotal Trial (Age 14-75). N=157. 16 US sites; 2020.

10. Medtronic data on file: HCP survey post virtual launch events conducted in Sept-Dec 2020 in UK, South Africa, Greece, Norway, Poland, Sweden and Belgium. Sample size = 558 HCPs.
11. Zhang G, et al. 986-P – Assessment of adhesive patches for an extended wear infusion set. 80th ADA International Conference, June 2020.
12. Ilany J, et al. Abstract 416 – Clinical study of a new extended wear infusion set design. 13th ATTD International Conference. February 2020.
*Refer to System User Guide – SmartGuard^TM feature. Some user interaction required.
**Glucose Management Indicator (GMI) data from CGM values were used to estimate HbA1c. Calculated using JAEB https://www.jaeb.org/gmi/.
***Compared with the MiniMed^TM 670G system.
^†A blood glucose (BG) reading is needed when entering SmartGuard^TM feature. If glucose alerts and CGM readings do not match your symptoms, use a BG meter to make diabetes treatment decisions.
^††Fast Pass is only offered for a limited time starting 1st March until commercial launch of next generation CGM technology.
Patients who are already using MiniMed^TM 780G and on boarded before the 1st March 2021 you are not eligible to register to fast pass. If your transmitter is within warranty at the time of launch we are considering upgrades using a separate channel
^†††At the time of manufacture and when the reservoir and tubing are properly inserted, your pump is waterproof.
^#Multiple Daily Injections (3 bolus and 1 basal insulin per day) requires 28 injections per week vs. one infusion set change every two to three days.
^##Versus SAP+PLGM or pre-AHCL initiation.